Drug-resistant "superbugs" represent one of the gravest threats in the history of medicine, leading experts warn.
Routine operations could become deadly "in the very near future" as bacteria evolve to resist the drugs we use to combat them.
This process could erase a century of medical advances, say British government doctors in a special editorial in The Lancet health journal.
Although the looming threat of antibiotic, or anti-microbial, resistance has been known about for years, the new warning reflects growing concern that Britain's NHS and other national health systems, already under pressure from ageing populations, will struggle to cope with the rising cost of caring for people in the "post-antibiotic era".
In a stark reflection of the seriousness of the threat, England's deputy chief medical officer, Professor John Watson, said: "I am concerned that in 20 years, if I go into hospital for a hip replacement, I could get an infection leading to major complications and possible death, simply because antibiotics no longer work as they do now."