Obese people are being warned they face a virtually impossible battle to lose weight because their bodies are programmed to regain any kilos they shed.
Professor of medicine at the University of Melbourne, Joseph Proietto, said once someone lost weight, changes in both energy expenditure and hunger-controlling hormones encouraged weight regain.
"It is likely that it is these physiological adaptations that make it so difficult to maintain weight loss," he wrote in an article published by the Medical Journal of Australia.
"Importantly, if this regulatory mechanism is operating in those who are already obese, public health messages encouraging people to eat healthy food and to exercise are unlikely to have long-term impact on their weight.
"Several studies have shown that although obese people who make the effort can achieve and maintain significant weight loss for one to two years, the weight is usually regained in the longer term."