They are coated in a substance found on the outside of woman's eggs that sperm latch on to.
Inserted into the womb in their millions, they acts as decoys, trapping the sperm before they reach the eggs.
In experiments in mice, animals with bead implants failed to get pregnant, despite being continuously mated. Further work showed the beads created a "dramatic" barrier to human sperm, the journal Science Translational Medicine reports.
Importantly, the contraceptive effect was long-lasting, so is likely to be attractive to women who don't want to have to remember to take a pill every day.
Professor Allan Pacey, a Sheffield University fertility expert, said the technology could help IVF doctors find the best sperm by looking at which ones bind particularly well with the beads - and therefore a woman's egg.