The findings come from a major study of more than 7000 Britons born in 1958 whose parents provided information about their children's exposure to bullying at age seven and 11.
Data on blood inflammation markers and obesity were collected when the participants were aged 45.
Professor Louise Arseneault, from the Institute of Psychiatry, Psychology and Neuroscience at King's College, London, said the findings showed that being bullied in childhood "does get under your skin".
"We should move away from this idea that bullying is part of growing up and acceptable," she said.
"Our study implies that early interventions in support of the bullied children could not only limit psychological distress but also reduce physical health problems in adulthood."
Up to a fifth of children are thought to experience bullying but some cope with it better than others.
Previous research has linked bullying to an increased risk of depression, anxiety, suicidal thoughts, poorer education and deficient social life.
The new study, published in the journal Psychological Medicine, points to serious physical as well as psychological effects that can have a major impact on long-term health.
The researchers took account of a wide range of social and lifestyle factors that might have influenced their results, including IQ, social background, smoking, diet and exercise.
After making statistical adjustments to exclude these effects, the findings remained significant.
Among the study participants, 28 per cent were bullied occasionally in childhood and 15 per cent frequently.
A fifth of men and women who had frequently been bullied had raised levels of an inflammation blood marker called C-reactive protein (CRP) compared with 16 per cent of those who had never been bullied.
High CRP levels are associated with narrowing of the arteries, which increases the risk of heart disease and strokes.
Victims of frequent bullying also had raised levels of fibrinogen, a blood protein which promotes clot formation.
Measurements of body mass index (BMI), which relates height and weight, showed that 26 per cent of women who had been occasionally or frequently bullied as children were obese at the age of 45.
In comparison, only 19 per cent of women who weren't bullied ended up obese.
- PAA