Charlotte Bronte probably died of it but these days hyperemesis gravidarum - the severe form of morning sickness experienced by the Duchess of Cambridge - is easily treatable.
Kensington Palace announced Kate's second pregnancy early because it is also marred by the condition that put her in hospital during her first pregnancy with Prince George.
Watch: Prince William: 'Thrilled' by second baby
Hyperemesis gravidarum, which translates as vomiting pregnant, is not a rare condition, according to midwife Rachel Cassie.