After contracting a severe ear, nose and throat infection in Africa, Princess Charlene will not be able to return to Monaco in May for her 10th wedding anniversary.
The royal, 43, will instead have to undergo multiple procedures in her native South Africa.
Charlene hasn't been back to Monaco since January, however posted in June that her husband Prince Albert and their twins Princess Gabriella and Prince Jacques, 6, visited her in South Africa.
"This year will be the first time that I'm not with my husband on our anniversary in July, which is difficult, and it saddens me," Princess Charlene said in a statement reported by the Daily Mail.