New study shows icing muscles after exercise ineffective, counter-productive

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After a particularly vigorous workout or sports injury, many of us rely on ice packs to reduce soreness and swelling in our twanging muscles. But a cautionary new animal study finds that icing alters the molecular environment inside injured muscles in detrimental ways, slowing healing. The study involved mice, not people, but adds to mounting evidence that icing muscles after strenuous exercise is not just ineffective; it could be counter-productive.

Check inside the freezers or coolers at most gyms, locker rooms or athletes' kitchens and you will find ice packs. Nearly as common as water bottles, they are routinely strapped onto aching limbs after gruelling exercise or possible injuries. The rationale for the chilling is obvious. Ice numbs the affected area, dulling pain, and keeps swelling and inflammation at bay, which many athletes believe helps their aching muscles heal more rapidly.

But, in recent years, exercise scientists have started throwing cold water on the supposed benefits of icing. In a 2011 study, for example, people who iced a torn calf muscle felt just as much leg pain later as those who left their sore leg alone, and they were unable to return to work or other activities any sooner. Similarly, a 2012 scientific review concluded that athletes who iced sore muscles after strenuous exercise — or, for the masochistically minded, immersed themselves in ice baths — regained muscular strength and power more slowly than their unchilled teammates. And a sobering 2015 study of weight training found that men who regularly applied ice packs after workouts developed less muscular strength, size and endurance than those who recovered without ice.

But little has been known about how icing really affects sore, damaged muscles at a microscopic level. What happens deep within those tissues when we ice them, and how do any molecular changes there affect and possibly impede the muscles' recovery?

So, for the new study, which was published in March in the Journal of Applied Physiology, researchers at Kobe University in Japan and other institutions, who long had been interested in muscle physiology, gathered 40 young, healthy, male mice. Then, using electrical stimulation of the animals' lower legs to contract their calf muscles repeatedly, they simulated, in effect, a prolonged, exhausting and ultimately muscle-ripping leg day at the gym.

Rodents' muscles, like ours, are made up of fibres that stretch and contract with any movement. Overload those fibres during unfamiliar or exceptionally strenuous activities and you damage them. After healing, the affected muscles and their fibres should grow stronger and better able to withstand those same forces the next time you work out.

But it was the healing process itself that interested the researchers now, and whether icing would change it. So they gathered muscle samples from some animals immediately after their simulated exertions and then strapped tiny ice packs onto the legs of about half of the mice, while leaving the rest unchilled. The scientists continued to collect muscle samples from members of both groups of mice every few hours and then days after their pseudo-workout, for the next two weeks.

Then they microscopically scrutinised all of the tissues, with a particular focus on what might be going on with inflammatory cells. As most of us know, inflammation is the body's first response to any infection or injury, with pro-inflammatory immune cells rushing to the afflicted area, where they fight off invading germs or mop up damaged bits of tissue and cellular debris. Anti-inflammatory cells then move in, quieting the inflammatory ruction, and encouraging healthy new tissue to form. But inflammation is often accompanied by pain and swelling, which many people understandably dislike and use ice to dampen.

Looking at the mouse leg muscles, the researchers saw clear evidence of damage to many of the muscles' fibres. They also noted, in the tissue that had not been iced, a rapid muster of pro-inflammatory cells. Within hours, these cells began busily removing cellular debris, until, by the third day after the contractions, most of the damaged fibres had been cleared away. At that point, anti-inflammatory cells showed up, together with specialised muscle cells that rebuild tissue, and by the end of two weeks, these muscles appeared fully healed.

Not so in the iced muscle, where recovery seemed markedly delayed. It took seven days in these tissues to reach the same levels of pro-inflammatory cells as on day three in the unchilled muscle, with both the clearance of debris and arrival of anti-inflammatory cells similarly slowed. Even after two weeks, these muscles showed lingering molecular signs of tissue damage and incomplete healing.

The upshot of this data is that "in our experimental situation, icing retards healthy inflammatory responses," says Takamitsu Arakawa, a professor of medicine at Kobe University Graduate School of Health Sciences, who oversaw the new study.

But, as Dr. Arakawa points out, their experimental model simulates serious muscle damage, such as a strain or tear, and not simple soreness or fatigue. The study also, obviously, involved mice, which are not people, even if our muscles share a similar makeup. In future studies, Dr. Arakawa and his colleagues plan to study gentler muscle damage in animals and people.

But for now, his study's findings suggest, he says, that damaged, aching muscles know how to heal themselves and our best response is to chill out and leave the ice packs in the cooler.

Written by: Gretchen Reynolds
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