She told the audience of delegates from over 190 countries that they "are the future, but also the present, driving the positive and necessary change needed across the globe."
She continued, "My husband has long advocated for important and necessary impact in the world, focusing a huge part of his life's work on the youth.
"So for both of us, bearing witness to the power you hold in your hands and the unbridled enthusiasm and energy that you have to see things come to fruition — it is just an absolute privilege."
She used her speech to talk about perseverance, recalling when she joined One Young World in Dublin and worked with a young woman from Eritrea who had "fled [her home country] with bullets fired above her head".
"I remember my shock, and I also remember her courage, my recognition of how much continues to go on each day with so many turning a blind eye.
"And yet despite all odds, she like so many still persevered."
Meghan said she "doubted herself" when she became a counsellor for the organisation because she was just the "girl from Suits".
"But One Young World saw in me what I wanted to see fully in myself, they saw in me just as I see in you the present and the future."
She said that before she spoke, she was able to meet with some of the delegates at the event, calling them "incredibly inspiring" and adding that "resounding themes came up" about "representation, inclusion and access".
"I am incredibly humbled to not just stand before each of you but to stand beside you.
"We often here people say the time is now but I'm going to double down on that by saying your time is now.
"The important work can't wait for tomorrow."
