"I started when I was 21 after my mum talked me in to competing in a pizza eating contest," Mrs Zisser told news.com.au.
"I qualified, and ate the pizza really quickly and had the best time. I beat 19 really big guys too.
"To do something like this you have to be fit....it's very difficult, so you have to have good fitness to do it."
Mrs Zisser said people often ask how she maintains her frame without putting on weight - especially when she challenges herself to eat 22 Big Macs in an hour, or a 10,000 calorie English breakfast in a single sitting.
"I walk around a lot, and I'm very busy but I don't go to the gym," she said.
"For me to eat 10,000 calories is very rare. The 4000 calorie Nutella challenge was the first I'd done in two or three months.
Your body doesn't process that many calories if you eat it in one go. I may weight a kilo more the next day, but the following week it evens itself out.
"I used to do challenges weekly, but I was gaining a lot of weight, so now I just do them every couple of months. So because I don't do this often, your body doesn't process that many calories if you eat it in one go. So I may weigh a kilo or two more the next day, but the following week it evens itself out."
Mrs Zisser, who films her eating for her Youtube channel, said the competitive challenges - which have seen her compete around New Zealand and in the US - often require consuming pizza, burgers, chips or other sweet foods.
To date, she's inhaled a 1kg burrito in under two minutes, 22 Big Macs in an hour, and even five foot-long Subway sandwich in under 10 minutes.
"This is basically a sport," the first-year medicine student said.
"I don't breathe while eating, your body stops you from doing that. So you do some practice ... but you don't really taste the food.
"With competitive eating, you're not really tasting the food. You change your senses, so you just eat for enjoyment.
"My husband finds it very entertaining, but it's something you have to want to do. I guess you're born to do it."