Having a lie-in at the weekend could raise the risk of diabetes and heart disease, say researchers.
Even moderate changes to the time you get up - such as waking early for work in the week or sleeping in on a day off - could lead to ill health.
Researchers have long recognised that shift workers can suffer increased ill-health because of the continual disruption to the circadian system, or natural body clock.
They are more likely to develop heart disease and Type 2 diabetes than employees with regular daytime shifts.
In the latest study, middle-aged individuals who got up at odd times were found to raise levels of fat in blood and reduce a compound that lowers blood sugar levels. The research, published in the Journal of Clinical Endocrinology and Metabolism, is the first to link so-called "social jetlag" in non-shift workers with metabolic illnesses, such as diabetes. Those behind the study said bosses would have to consider the impact of work on sleep and health.