The 24-year-old went into Sunday night's match following a similarly sapping encounter on Friday, beating Andy Murray in four hours and 50 minutes. He is the tour weakling no longer, a transformation that has come about through an eclectic combination of hard work - Djokovic's warm-ups are notable for their intensity - a change in diet and a space-age pod that may or may not have any real benefit.
The Australian Open marks the start of the tennis year. It is when the players are at their fittest and freshest, but Djokovic's feat impressed sports scientists for his ability to produce two such marathon performances with minimal recovery time.
"It's a phenomenal effort, a phenomenal aerobic and endurance performance," said Craig Boyd of the Institute of Performance Research at Manchester Metropolitan University.
Diet is one area Boyd and Karl Cooke, the Lawn Tennis Association's sports science manager, highlight in Djokovic's relentless advance from contender to leader of the hungriest pack the sport has seen. In 2010 Djokovic sought the advice of Igor Cetojevic, a nutritionist who holds a diploma from the Indian Institute of Magnetotherapy in Delhi and has studied traditional Chinese medicine. Dr Cetojevic found that Djokovic suffered from Celiac disease and instructed him to cut gluten out of his diet. Since doing so Djokovic has won four Grand Slams.
The most controversial part of Djokovic's improvement has been his occasional use of a CVAC Pod. The NZ$95,500 device resembles something from a Spinal Tap set and is supposed to aid an athlete by simulating high altitude and compressing muscles at rhythmic intervals. The World Anti-Doping Authority takes a dim view of such equipment, although it is not illegal. The scientific community is divided as to its effectiveness.
"There is not always a lot of scientific evidence to back up what he is doing," said Dr Cooke.
"But he strikes me as someone who is constantly looking at any small thing that can help him last a bit longer or train harder or recover a little bit better."
This is the greatest era in men's tennis, as Federer and Nadal jostle with Djokovic for dominance, and with Murray not far behind.
"People are increasingly looking for those margins where they can beat their opponent," Dr Cook said.
Djokovic reflected on his triumph.
"You're going through so much suffering your toes are bleeding. It's outrageous but you're still enjoying the pain," he said with a smile, the man Roddick once teased for fearing a "common cold".
- INDEPENDENT