Sir Elton John has promised to boycott Dolce & Gabbana after the brand's leading designers said that children born by IVF are "synthetic".
Domenico Dolce and Stefano Gabbana spoke out against same-sex families, despite being gay themselves, saying: "We oppose gay adoptions. The only family is the traditional one.
"No chemical offsprings and rented uterus: life has a natural flow, there are things that should not be changed."
Sir Elton, who has had two children by IVF with his husband David Furnish, wrote on Instagram: "How dare you refer to my beautiful children as 'synthetic'.
"And shame on you for wagging you judgemental little fingers at IVF - a miracle that has allowed legions of loving people, both straight and gay, to fulfil their dream of having children.