A number of famous people are known to have creased ear lobes, including film director Steven Spielberg, 70, and actor Mel Gibson, 61.
In the study, published in the American Journal of Medicine (AJM), the researchers said they found 78 of 88 patients who had suffered a full-blown stroke (88 per cent) had creased ear lobes.
That also applied to 112 of 153 (73 per cent) of patients who had experienced a 'mini-stroke' - more formally called a transient ischaemic attack. Previous research has also linked the ear creases with a higher heart attack risk.
In one study of 800 people, 77 per cent of those who had suffered an attack had the crease, compared to 40 per cent of those in a group of non-heart attack victims. Frank's sign is named after the American doctor Sanders T Frank, who noticed in 1973 that the ear lobe crease was common in young patients with the heart condition angina. Besides the theory that the creases indicate clogged arteries, another possibility is that they are a sign of accelerated ageing.
Creased earlobes are not the only visible indicator of potential health problems. Another sign that a person is at increased risk of heart disease or stroke is a receding hairline or bald patch. That holds true for both sexes, although it is much more common in men.
A pot belly also indicates a raised risk, even if the person is otherwise quite slim.
Last night, a British stroke expert said the Israeli researchers' study into Frank's sign should be treated with caution.
Dr Yaqoob Bhat, clinical director for stroke medicine at the Aneurin Bevan University Health Board in South Wales, said: "The so-called Frank's sign in the ear lobes has been recognised as having a possible association with advanced age, but some studies have shown its association with cardiovascular risk factors like diabetes, hypertension, ischaemic heart disease, and peripheral vascular disease.
"This new study suggests an association with increased risk of stroke, but further studies are needed to assess its importance."