'Spicer' quickly grows adversarial, shouting "I am here to apologize on be half of you to me," referring to how he feels he has been treated in the past few weeks.
McCarthy continues: "That apology is NOT accepted, cause I'm not here to be your buddy, I'm here to swallow gum and to take names."
The sketch focuses around the Press Secretary's propensity to lash out at the media, and includes jabs at CNN and Glenn Thrush of the New York Times.
When describing a recent public event held by the President, the Spicer impersonation yells 'Everyone was smiling, everyone was happy, the men all had erections, every single one of the women was ovulating left and right, and no one, no one was sad.'
Later, in an impersonation of Spicer taking questions from the press, he quickly grows frustrated at journalists asking about the role of chief strategist and key adviser Steve Bannon, turning to props to explain the President's executive order.
When talking about radical Islamic terrorism, holds up a stuffed moose and a stuffed lamb, and said 'He will not be deterred in his fight against radical moose-lambs.'
To finish off the sketch, 'Spicer' introduces education secretary nominee Betsy De Vos, played by Kate McKinnon, who says that she knows practically knows nothing about schools, but does know that they should have 'walls, and roof, and gun for potential grizzly,' before being hurried off the stage.
The sketch was quickly applauded on social media sites like Twitter, where Melissa McCarthy was the trending topic for many hours on Saturday night.
Some Twitter users even went to far as to say that this might be the best impersonation sketch done in years, and many calling for Spicer's character to be a recurring one in future SNL skits.