"It's totally Bill. I can vouch 'cause I'm the one in the photo with the massive grin thinking 'oh my god this is going to be an awesome photo!'" she explained.
She joked: "It's already going to be the first picture we show future girlfriends. If they don't know who Bill Murray is they're out the door."
The photo has attracted dozens of comments, one said: "This picture is important. I personally feel like it's irresponsible to not share this with as many people as humanly possible.
Rebecca Huska wrote: "What I learned from the comments: When Bill Murray is crying, he starts to look like Tom Hanks."
Another wrote: "Totally thought that was Tom Hanks..."
More from Spy:
• Orange is the New Black star admits 'alcohol problem'
• Rihanna's plea for help over missing dancer
Hanks also appears to enjoy having photos taken with fans after grabbing a selfie with a couple on their wedding day in Central Park last month.
New York City photographer Meg Miller was capturing couple Elisabeth and Ryan's big day when The Green Mile actor came over to say hello.