While reality TV queen Kardashian managed a slight smile, West remained stony faced as the blonde haired actress lay "helpless" on the carpet.
Schumer later composed herself just in time to pose alongside movie hunk Bradley Cooper, 40, and showed off lots of cleavage in her tight fishtail frock, accessorizing with a small pink handbag.
Meanwhile, fellow honoree Laverne Cox could be seen behind the group on the red carpet laughing at the entire incident.
Also getting a laugh out of Schumer's pratfall was Kardashian's bodyguard Pascal Duvier, who could be seen giggling at the prank.
Schumer later told People that Kardashian thought it was "really funny". She said:"I saw them, and I asked my publicist, 'Can I dive in front of them and act like I fell?' And she said, 'I can't stop you'."
"I talked to them. They were like, 'What?' Kim was worried for me, and I think Kanye was just, like, scared that I was doing something. They were really sweet. Kim was really funny. She goes, 'Oh my god, I was like, does this girl need help?' She was like, 'That was really funny'."
It was a big night for Kimye as the couple were among those named individually as Titans in the weekly publication.
Others who were named 'Titans' included Saturday Night Live creator Lorne Michaels, Apple CEO Tim Cook, Lee Daniels, and restaurateur Danny Meyer of Shake Shack fame.
West was also featured on one-of-five special edition covers for the Thursday April 16 issue, along with Bradley Cooper, journalist Jorge Ramos, Ruth Bader Ginsberg and ballerina Misty Copeland.
The annual list is assembled by the American news magazine and has featured several big names since it was first published in 1999 including: Barack Obama, Oprah Winfrey, Hillary Clinton and Steve Jobs.
Winfrey and Obama have both appeared on the list ten times, while Clinton has been named on nine different occasions.
Last year's covers featured Beyoncé, Robert Redford, openly gay NBA player Jason Collins and General Motors CEO Mary Barra.
- Daily Mail
