But when JoJo discovers his mother his hiding a young Jewish girl in their attic, he has to confront everything he believes in.
The trailer doesn't give away too much more about the story, but it does give us our first glimpse at the rest of the cast in action, including Aussie comedian Rebel Wilson as Fräulein Rahm, Game of Thrones' Alfie Allen as Finkel and Scarlet Johansson as JoJo's mother Rosie.
The trailer's debut comes just days after Waititi was confirmed to be returning to Marvel's Thor franchise to direct the fourth film, Thor: Love and Thunder.
That project will see Waititi team up with Chris Hemsworth and Tessa Thompson again, but this time he'll also work closely with Natalie Portman who will play Thor.
Until then, JoJo Rabbit will get its official debut at this year's Toronto International Film Festival in September. It is due to hit cinemas in New Zealand on October 24.