Anthony flailed his arms around during his eccentric dance and bobbed the camera up and down in a dizzying pattern.
Perhaps feeling slightly overworked, the actor - who has consistently appeared on the big and small screen for over 50 years - gave a small glimpse into his mindset after captioning the video: 'This is what happens when you're all work and no play...'.
His caption could be referring to the old proverb of overworking leading to dreadful boredom, popularised by Jack Nicolson in hit 80s horror flick The Shining.
Fans were both puzzled and highly amused by Anthony's crazy antics, taking to the micro-blogging site to vent their confusion and delight.
'With all due respect, Sir Anthony, that is THE single most peculiar thing I've seen all day.' wrote one fan about the new viral sensation.'
Another added: 'That video of Anthony Hopkins dancing is scarier than the whole Hannibal franchise.', while a third commented: 'For about 30 seconds now, I was utterly convinced Jack Nicholson and Anthony Hopkins were the same person.'
'This is literally the scariest thing Anthony Hopkins has ever done.' said one petrified fan, as one more said: 'Why did I feel that Hannibal was chasing me while watching this video?'
