His eyes, eyebrows, nose, lips, chin, jaw and facial shape were measured and came closest to the Greeks' idea of perfection.
Bradley Cooper came second with 91.80 per cent, Brad Pitt was third with 90.51 per cent, One Direction singer and Dunkirk star Harry Styles was fourth with 89.63 per cent and David Beckham was fifth with 88.96 per cent accuracy of his features to the beauty ratio Phi.
Dr De Silva, who runs The Centre For Advanced Facial Cosmetic And Plastic Surgery in London, said: 'George Clooney has been feted as the world's most beautiful man for decades - and it is great that his status has now been proved by science.
The world's top ten most handsome men
1 George Clooney 91.86%
2 Bradley Cooper 91.80%
3 Brad Pitt 90.51%
4 Harry Styles 89.63%
5 David Beckham 88.96%
6 Will Smith 88.88%
7 Idris Elba 87.93%
8 Ryan Gosling 87.48%
9 Zayn Malik 86.5%
10 Jamie Fox 85.46%
'He has beautiful facial symmetry and gets closer than any other man to having what the Greeks considered the perfect face.
'George had a near perfect ratio of nose to lip dimension of 99.6 per cent and his chin and eye spacing were almost perfect as well. Across the 12 key markers he had the highest combined score.
'These brand new computer mapping techniques allows us to solve some of the mysteries of what it is that makes someone physically beautiful.
'The Phi ratio of 1.618 has long been thought to hold the secret of beauty, and now with the computer mapping we can calculate exactly how it applies to men.'
The Golden Ratio was a mathematical equation devised by the Greeks in an attempt to measure beauty.
While the ratio can be applied to anything and was used by Leonardo Da Vinci for the perfect human male body in his famous work the Virtruvian Man.
The premise behind this is that the closer the ratios of a face or body are to the number 1.618, the more beautiful they become.
How to calculate your own Phi face score
Take a picture of your face close up on your phone, don't smile and look straight forward and have your hair off your face. Print out the picture on an A4 piece of paper.
Nose
• Measure the length of the nose from its widest point at the nostril = Nose length.
• Measure the width of the nose at its widest point = Nose width.
• Divide the nose length by nose width = your nose ratio.
• If bigger than 1.618 then divide 1.618 by your nose ratio
• If smaller than 1.618 then divide your nose ratio by 1.618
• That will give you your percentage score of Nose Phi score.
Eyebrows
• Measure your eyebrow from the end nearest your nose to the arch in a straight line = Arch Length
• Measure your eyebrow from the same end to the opposite tip in a straight line - Full Length
• Divide the Full Length by the Arch Length = Eyebrow Ratio
• If bigger than 1.618 then divide 1.618 by your Eyebrow ratio
• If smaller than 1.618 then divide your Eyebrow ratio by 1.618
• That will give you your percentage score of Eyebrow Phi score.
Lips
• Measure the length of the lip from end to end = Lip Length
• Divide Lip Length by Nose Width = 1.618 if perfect.
• The distance from the corner of the lip to the opposite edge of the nose should also be equal to Base of Nose x 1.618.