"All the characters have gone their separate ways. I always have this standard go-to joke when people say, 'We want to see what Joey's doing now.' Nobody wants to see Joey at his colonoscopy. Nobody wants to see that."
Before LeBlanc, David Schwimmer was the last Friends star to be asked about a potential reunion.
"Look, the thing is, I just don't know if I want to see all of us with crutches [and] walkers," Schwimmer said on Megyn Kelly Today in January.
"I doubt it — I really doubt it. But thank you for asking, and moving on."
Before Schwimmer it was Matthew Perry's turn to respond to the question and he told Vanity Fair in June last year why he has no interest in a Friends reunion.
"I have this recurring nightmare — I'm not kidding about this. When I'm asleep, I have this nightmare that we do Friends again and nobody cares," Perry told the magazine.
"We do a whole series, we come back, and nobody cares about it. So if anybody asks me, I'm gonna say no. The thing is: we ended on such a high. We can't beat it. Why would we go and do it again?"
A few months earlier Lisa Kudrow was asked the exact same question during an appearance on the US Today show.
"I don't see it happening," Kudrow said at the time.
"It would be fun, but what would it be about? Think about it. The thing we liked best about the show was that they were 20-somethings and they were their own family. Now, they all have families, so what are we going to watch?"
And it's not just the stars of the show who get asked the question. Friends creator Marta Kauffman was quizzed about a potential reunion back in 2016 and her response was crystal clear.
"There will never be a Friends reunion movie," she said.
They've all been pretty clear that it's not going to happen, but one thing's for sure, the stars of Friends can still expect to be answering the same question for many years to come.