She also wowed the crowd, who she referred to as "the Scots" with a medley which included some of legendary Scottish duo The Proclaimers' 1988 hit I'm Gonna Be (500 Miles).
Despite her expletives, Mnaj proved to be a popular choice as host and took to her Twitter account to retweet hundreds of positive remarks about her presenting performance.
One fan wrote: "honestly, I'm speechless about tonight queen, you've made mine and many others night, congratulation (sic)"
Another supporter posted: "you were so amazing tonight I love you so much (sic)"
Nicki posted a picture of herself in the ruffled hem dress she arrived on stage in and thanked the people of Scotland for giving her such a warm welcome at the ceremony.
In a caption attached to the image, she wrote: "This dress by Peter Hidalgo. MTV, thank you. SCOTLAND, thank u. (sic)"
Minaj also didn't disappoint in the style stakes, changing her look no less than eight times after coming in on wires in her outrageous ruffled outfit.
One Direction were the big winners on the night as they won a hat-trick of awards - Best Pop, Best Live and Biggest Fan.
Accepting the Biggest Fan accolade via video-link, Harry Styles paid tribute to their supporters, known as Directioners, saying: "We're so sorry we can't be with you tonight. Thank you so much for this, the award for Biggest Fans.
"Because of that we obviously, obviously want to thank our incredible fans - thank you so, so much for all your support. We can never thank you all enough."
Ariana Grande won Best Female and Best Song for hit Problem, featuring Iggy Azela, while Justin Bieber got the nod for the Best Male prize.
Katy Perry and 5 Seconds of Summer were also among the winners, while Ozzy Osbourne took home the Global Icon award.
- Bang! Showbiz