The win for Rami - who was born in Los Angeles to Egyptian parents - is also a positive step towards a more diverse award ceremony, and the Need For Speed actor admitted his win means the industry can continue to "strive to be as progressive as possible".
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He said: "For me to stand here as not the typical leading man and coming home with this speaks a lot about where we are headed.
And we can go further in that direction, not just in entertainment, but socially and politically, to strive to be as progressive as possible."
And Rami - who won his award for his portrayal of the socially awkward and reclusive Elliot Anderson in the hit series - also made sure to honour outcasts everywhere when he accepted his award, saying there was "a little bit of Elliot in all of us".
He said: "I play a young man who is, like so many of us, profoundly alienated.
And the unfortunate thing is I'm not sure how many of us would want to hang out with a guy like Elliot. But I want to honour the Elliots, cause there's a little bit of Elliot in all of us."