Offering an explanation for the awkward exchange, he continued: 'She was going through a bad time, broke up with her boyfriend, but she...'
Eamonn was quick to interrupt, explaining: 'We should say that they are contractually obliged to do interviews with their film deals.'
But Michael continued to offer an explanation, reasoning: 'She was at the end of a tour and was tired,' before adding: 'I don't know why I'm making excuses for her!'
Ruth Langsford also couldn't understand why Michael was defending Meg, interjecting: 'No, don't she was just rude!' as he uttered: 'You can't behave like that'.
MailOnline have contacted Meg's representatives for comment.
Michael famously interviewed the You've Got Mail star, 55, on Parkinson in 2003 in an exchange that went down in chat show history.
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During the chat, Meg offered several one-word answers and when she acknowledged that she wasn't comfortable with the interview, she suggested that he 'just wrap it up.' After the interview, Meg claimed that the star was a 'nut' and said that she was 'offended' by his 'disapproving father' tone.
Meanwhile, Eamonn is also said to have had a tense exchange with Meg as he claimed that other chat show hosts 'should not bother' speaking to her. Speaking on RTE's 2fm, he recalled: 'I did her before Parky. Nobody believes me.
'Everybody would say: "Aw, but she's Sleepless In Seattle, she's When Harry Met Sally, she's sweetness, she's lovely".
'She's the world's worst example, maybe, of actors who see themselves as empty vessels. When they're given a role they are somebody and they can talk but they're not comfortable or can't talk about themselves.
'She's painfully, painfully aware of herself and really, just honestly, don't ever bother. Don't go there if you're offered.'