The 30-year-old pop star thinks all women share many of the same life struggles and has admitted the situation is pulling her "apart".
She reflected: "Many women, no matter their race, colour, religion, go through the same issues with men, bodies, minds. A lot of women shut down, as they don't feel heard. It ain't easy. I know it is pulling me apart."
Gaga - whose real name is Stefani Germanotta - revealed she touches on these issues in one song on her much-anticipated new album Joanne, which is a tribute to her father's sister, who died from lupus.
She told the Sunday Times newspaper: "This is about an unconditional love women should have for each other."
She explained: "It is quite simple. I'd like women to hear the song and, when they walk into a bar and see a girl they've never met, they just go, 'Hey girl!' And that means, I know. We're in this bar, and these men are foolish, but I got you..."
Gaga also conceded that her new record is less naive than ones she has previously released.
She said: "I'm older and in a strong state of reality, trying, with statements about positivity and love, to speak in a way that is not too naive, perhaps, in a way where people who live in this world can relate to what I'm saying, as opposed to feeling it's la-di-da...
It's about using words and allowing the pain I feel to exist on the record, and not to hide it with anything. I'll say that.
"My mother cried when I started recording [this]. I asked 'What's wrong?', and she said, 'There's so much pain in your voice now.'"
The star also thinks everyone in the world is trying to "keep up" a perfect image of themselves.
She shared: "I believe everybody has a Joanne in their life. Everybody has someone they've either lost or is a pending loss.
"In this world, we're all trying to keep up, put a perfect image out of who we are."
Gaga explained that each of the tracks on her eagerly awaited new album is personal to her.
She told the Sunday Times newspaper: "I'm not sure I'd go into detail about it, but Joanne gave me strength to live the rest of the life she didn't get to have.
"I guess, I think, if I can heal one person, maybe I can heal two, five, ten million. If I could just heal my dad, then maybe [I] might heal someone else."
Meanwhile, Gaga - who is well-known for her outrageous fashion sense - revealed she is keen for people to play closer attention to her lyricism on the new album, rather than paying attention to peripheral issues, like what she's wearing.
Gaga said: "It becomes about everything else, and that was what I [once] wanted. But if I wear a black T-shirt and black pants every day, [people] might listen to what I write."
