Fans quickly flooded the post with comments about her appearance.
"Khloe it's time to grow up and stop with these ridiculous filters you use it's getting embarrassing," one fan wrote, while another said the Keeping Up With The Kardashians star "looks different every week".
"Girl stop that is not you," said a third, with a fourth person adding "Where is Khloe?!"
But when one person commented, "money spent well" Saturday morning, Khloe was quick to clap back.
"The shade of it all" she responded, alongside three crying-laughing emojis.
The images show Khloe with her hair sleeked back in two half pony ponytails, with some pointing out, "Ariana Grande vibes" — referencing the singer's signature hairstyle.
"I thought this was Ariana Grande for a sec," one fan wrote.
Even sister Kylie Jenner commented: "Love this hair on u. So pretty."
Others also defended Khloe's look with producer Elaine Thomas telling the star, "You are GORGEOUS!" to which she replied, "awww I love you".
Meanwhile celebrity make-up artist Etienne told Khloe she looked "Hotttt" alongside a flame emoji.
Khloe later took to Twitter to address some of the backlash from the photos, writing: "I'll never understand how bored or unhappy some people can be. I am someone who would never comment something unless it's positive.
"I believe in uplifting and complimenting one another. Who has the time chiiiillllldddd?! Time is precious boo. I'm spending it on happy things."
The reality star then added, "With that being said, I love you guys!!