It will be the couple's first biological child. They are already parents to two adopted two girls, four-year-old, Adelaide,and seven-year-old, Naleigh Moon.
"The Kelley clan is thrilled to announce that we are expecting a third addition to our family," the couple told People in a statement.
"This is an incredibly exciting time for us filled with hope, anticipation, and hormones. Well, only I'm filled with hormones, but everyone in the family gets to enjoy them," Heigl joked.
"We couldn't be more excited to be able to finally share this news with our fans and are looking forward to continuing to share the journey with you all. xoxo, Katie and Josh."
Heigl, best known for her role as Izzie on Grey's Anatomy, was most recently seen in the television drama State of Affairs. The show was cancelled in 2015 after only one season.