Kanye later decided to put the feud to bed after Wiz claimed the "KK" he referenced in an earlier tweet meant marijuana.
The pair initially came to blows after Khalifa mocked West for deciding to change the title of his forthcoming album.
West hit back: "First of all, you stole your whole s**t from Cudi", and then added: "Second, your first single was corny as f**k and most there after."
But things took a turn for the worse when West brought Khalifa's relationship with Amber Rose, with whom he has a son Sebastian, into the bitter feud.
West, who dated Amber before he started his relationship with Kardashian, said: "3rd no one I know has ever listened to one of your albums all the way through. 4th you let a stripper trap you. 5th I know you mad every time you look at your child that this girl got you for 18 years. 6th don't ever come out the side of your neck at me.(sic)"
The 38-year-old rapper has now removed his rant from his Twitter page.
- Bang! Showbiz