Jimmy Fallon comes prepared to meet Hillary Clinton with mask and sanitiser

Jimmy Fallon took no chances when interviewing Democratic presidential candidate Hillary Clinton. Photo / Getty

Jimmy Fallon wasn't taking any chances as he prepared to meet the Democratic presidential nominee for their interview.

After he welcomed Hillary Clinton to the show in front of a cheering crowd, Fallon immediately took precautions.

The Tonight Show host pulled out a surgical mask and put it over his face as Clinton laughed hysterically.

'Thank you so much. It is great to have you here,' Fallon said as the two high-fived.

As Clinton found the joke, which seemed to be a swipe at the controversy over her recent 'medical episode', hilarious, Fallon then pulled out some hand-sanitizer to cleanse his hand.

Democratic presidential candidate Hillary Clinton says she has been accused of being 'too serious' by the Republicans. Photo / AP

The two then got down to business as they chatted about how hard it can be to be a woman on the campaign trail and how some people say she's too serious.

"It's especially tricky for women. It just is. Because there are a lot of serious things.

"The other night I was on a show and being asked about ISIS and Iran and I was serious. These are important issues that the country needs to talk about.

"And the Republicans were saying, 'Oh she looks so serious'. Well you don't talk about ISIS with a big grin on your face.

"They're a barbaric, evil group that we have to defeat and wipe out."

Clinton said it's a "constant balancing act" as she tries to "keep the energy and the positive spirit" while also taking seriously those important issues.

And after getting acquainted with Donald Trump's hairdo, time will tell if his interview with Clinton will go over better than his talk with Trump, which was highly criticised.

Republican presidential candidate Donald Trump had his famous 'do ruffled when he appeared on Jimmy Fallon's show. Photo / NBC