They first met while filming the pilot episode of Friends in 1994 and have been close ever since.
On Thursday Jennifer Aniston and Courteney Cox had a mini Friends reunion, attending the AFI Gala in Los Angeles, reports news.com.au.
The close friends walked the red carpet in co-ordinating black dresses and posed for photos together.
Inside the event Aniston and Cox made an appearance on stage to pay tribute to George Clooney, a long time friend of the pair who was receiving a lifetime achievement award at this year's gala.
Earlier this year Aniston sparked rumours that a Friends reunion episode was in the works during an appearance on The Ellen DeGeneres Show.