"How do I explain the fact that I got a GQ Man of the Year award and no women's magazines and no women's organisations have supported me?," McGowan said, in the explosive interview.
"I know these people, I know they're lily-livered, and as long as it looks good on the surface, to them, that's enough."
McGowan also took aim at Oscar-winner Meryl Streep again, saying it was "literally impossible" that she didn't know about Weinstein's history of abusing actors.
HARVEY'S HISTORY OF ABUSE
Just over a year ago, Oscar-winning mogul Weinstein was hit by a bombshell article in The New York Times, followed by another in New Yorker magazine, accusing him of a career of sexual harassment, assault and rape.
Since then, multitudes of women have come forward alleging 40 years of impropriety that sparked a sexual harassment watershed, ending the careers of powerful men.
It ignited a global call to arms, under which tens of thousands of women took to social media to share their stories of abuse under the #MeToo hashtag.
"I came of age in the '60s and '70s, when all the rules about behaviour and workplaces were different," the 66-year-old said in a bizarre statement soon after the scandal blew up that apologised yet appeared to justify his behaviour.
"That was the culture then." While he denies any non-consensual activity, he disappeared from public life, surfacing occasionally from reported sex addiction treatment, his name toxic and his reputation in tatters.
The list of stars levelling abuse accusations against Weinstein is long: McGowan, Angelina Jolie, Gwyneth Paltrow, Lea Seydoux, Rosanna Arquette, Cara Delevingne and Salma Hayek, to name a few.
'TERRIBLY NAIVE'
Hayek accused the magnate of threatening to "break my kneecaps" after she spurned his advances on the set of her film Frida. The one-time Democratic Party donor, who hobnobbed with Hillary Clinton and once had a personal fortune estimated at $150 million, has faced an avalanche of lawsuits.
He is out on $1 million bail and has pleaded not guilty in New York to six counts allegedly committed against three women in 2004, 2006 and 2013.
The accusations of predatory sexual assault, criminal sexual acts and rape in the first and third degree could see Weinstein jailed for life if convicted.
But the former Hollywood legend, who for decades produced box office and critically acclaimed hits, has been forced to accept that his career is over, regardless of whether he is convicted.
He has been expelled by the Oscar-awarding Academy of Motion Picture Arts and Sciences and sacked by his own studio, The Weinstein Company, which has since been sold for a reported $289 million and broken up.
Weinstein's British fashion designer wife is divorcing him and his property empire is being sold.
"There was a part of me that was terribly naive … I had what I thought was a very happy marriage. I loved my life," Georgina Chapman, his estranged wife and mother of two, told Vogue magazine.
