Accessed mainly by private shuttle from St Mark's (few guests bother with the rear pedestrian entrance) and set in acres of landscaped gardens containing one of central Venice's very rare hotel pools, the Cipriani has an elegantly converted 19th-century Granary where much of the shindig will be staged, the hotel's PR machine says.
But the Gabbiano bar and newly opened Adam Tihany-designed Oro Restaurant - under the talented direction of chef Davide Bisetto - will also come into play: fine weather forecast for the weekend would allow guests to spill out on to the utterly dreamy lagoon-side tables in the garden. (There's a good view of this area from the launch that ferries guests to the St Regis hotel on the island of San Clemente.)
The Cipriani says that they expect the couple to stay in one of their suites - possibly the exclusive Palladio Suite (£6,365 per night), with its private garden, hot tub and boat jetty, which would make a fine bridal nook.
But canny wedding-watchers are putting their money on the ceremony taking place at the tight-lipped 24-room seven-star Aman Canal Grande, which is also fully booked this weekend.
If the Clooneys decide to decamp to the Aman in an attempt to throw off the paparazzi, the £3,130-a-night Alcova Tiepolo suite seems a likely choice: a cascade of decorative stucco surrounds the head of a bed with a fresco by 18th-century Venetian maestro Gianbattista Tiepolo on the ceiling above; original chinoiserie fabrics adorn the walls in the living room. There's space in the hotel's two gorgeous, high-walled gardens for aperitivi and dining, and a kitchen producing Asian cuisine which may turn its hand to Middle Eastern dishes for the Lebanese side of the bride's family.
And the wedding itself? Giorgio Armani has announced that he is responsible for the groom's outfit. Alamuddin was giving little away when she was snapped in Milan airport earlier this week with a Stella McCartney suitbag slung over her shoulder and clutching a label-less bandbox which may have contained The Dress. She was, however, spotted in London recently emerging from the HQ of Alexander McQueen, where designer Sarah Burton produced the Duchess of Cambridge's lacy wedding number.
Local press has tipped Walter Veltroni, a close Clooney friend and former mayor of Rome, to officiate at the ceremony itself... wherever and whenever that may be. In theory, the couple will have to drop by the Rialto-facing Palazzo Cavalli - city hall's wedding venue - to do the required paperwork. While international media expect the match to be made official on Saturday, local press are predicting a post-party appointment on Monday, September 29. Paparazzi aspiring to immortalise the moment will have to have their wits about them: when Woody Allen married Soon-Yi Previn here in 1997 - the last big-name wedding in the lagoon city - they were spirited in and out of a side entrance before anyone noticed they were there.
Due to privacy concerns, no official information is available about the four-day fest, which starts on Friday night. Unconfirmed reports suggest Cate Blanchett, Matt Damon, Bono, Cindy Crawford, Brad Pitt and Angelina Jolie are among the attendees.
The 36-year-old, Lebanese-born Alamuddin, who is usually based in London, was seen at Milan airport on Wednesday, while there have been no sightings of Clooney so far. The bride-to-be held a garment bag from the Stella McCartney fashion label, possibly containing her wedding dress.
Italian tenor Andrea Bocelli and US pop star Lana Del Rey are expected to provide musical entertainment, the Corriere del Veneto newspaper wrote, adding that most celebrations will take place in the five-star Belmond Hotel Cipriani.
However, guests will be moved to the seven-star Aman Canal Grande - a 16th-century palazzo overlooking Venice's main waterway - for dinner on Saturday, partly because the Cipriani had already been booked for another wedding, Corriere del Veneto said.
It will be Clooney's second wedding, after his 1989-93 union with actress Talia Balsam. He is often seen in Venice - usually to attend the lagoon city's film festival. He also owns a villa overlooking Lake Como, near Milan.
The 53-year-old is said to have asked former Rome mayor Walter Veltroni to officiate a civil wedding ceremony on Monday. Crawford's husband Rande Gerber is expected to be the best man, while Alamuddin's sister Tala will be the maid of honour.
The Municipality of Venice was not available for comment.
Clooney had announced plans to tie the knot in Venice this month.
At a charity gala in Florence, he said: "I would just like to say to my bride-to-be Amal that I love you very much and I can't wait to be your husband. I met my bride-to-be in Italy, and I will be married in Italy soon, in a couple of weeks ... in Venice, of all places."
- DPA and Daily Telegraph