"And incuriousness has become cool. It's celebrated. It doesn't make sense to me."
Kardashian swiftly fired back, branding his comments as "careless".
Taking to her Twitter page last week, she wrote: "I just heard about the comment Jon Hamm made about me in an interview. I respect Jon and I am a firm believer that everyone is entitled to their own opinion and that not everyone takes the same path in life," Kardashian wrote.
"We're all working hard and we all have to respect one another. Calling someone who runs their own businesses, is a part of a successful TV show, produces, writes, designs and creates 'stupid' is, in my opinion, careless."
Hamm later downplayed his rant, telling E! Online his Kardashian slam was "not personal".
"It's surprising to me that it has become remotely a story. I don't know Ms Kardashian, I know her public persona," he said.
"What I said was meant to be more on pervasiveness of something in our culture, not personal, but she took offence to it and that is her right."
All is forgiven? I should cocoa.
"I don't think [my comments] were careless. I think they were accurate," Hamm told Matt Lauer on the Today Show.
"It's a part of our culture that I certainly don't identify with, and I don't really understand the appeal of it other than in a sort of car crash sensibility, and it's not something that I partake in or enjoy, but it is what it is, and here we are."
Hamm's Mad Men co-star Vincent Kartheiser also piped up, adding his two cents worth.
"I agree," he said. "He said it very eloquently. I agree with everything he said. I think our society enjoys to turn on the television and see someone who's maybe awful and they can say, 'Maybe I'm not as terrible as that person'."
Chimed Hamm: "There are a lot of channels on the dial and those channels need to be filled up with things. It's different strokes for different folks."
He also addressed the stink during a recent interview with Anderson Cooper.
"It gets rementioned and rerementioned on further television shows and here we are," he told Cooper.
"It's amazing, I'm in a Twitter feud. I don't have a Twitter account and I'm not a big fan of feuding, so it's a very strange place to be."
Kardashian has yet to respond.
Watch Hamm and his Mad Men co-stars speaking to Matt Lauer below:
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* One more time (and for the last time) for the cheap seats: Do you agree with Hamm, or do you think Kardashian is being given a raw deal?
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