Kanye went on to claim "the media" didn't want him and Kim to be together and said he'd spoken to his pastor about his marriage and "wanting to put his family back together".
He pointed the finger at his wife's publicist, suggesting she is behind Kim's decision to file for divorce.
"Then they have people all around and in my wife's ear, you know, this publicist that's next to her — I don't f*** with her," he said.
"That's my family E! That's my family Hulu."
The "Bound 2" hitmaker revealed he had confronted Drake on a group text - which included Kim, Kid Cudi, Pusha T, Travis Scott and Jay-Z - about the "Hotline Bling" singer's lyrics suggesting he had slept with the "Keeping Up With the Kardashians" star.
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"One of the lines I said that was legend was, 'I'm worth more than all of y'all on this text combined'.
"I had this conversation with Drake that's like, 'I never f***** Kim,' but I was like, 'But you acted like you did … Did you ever DM her? Everything else around it—you know, 'cause it ain't about just the actual act of it."
Elsewhere in the interview, the "Monster" rapper admitted he hasn't been fully vaccinated against coronavirus yet, which has made travel difficult.
He said: "I travelled to Paris a couple weeks ago and I had to go through Lisbon 'cause you can go through Lisbon without being vaccinated.
"I only got one of the shots, so I'm 'halfcinated.' And Lisbon is a 15-hour ride."