Before tying the knot with Amal, the Monuments Men star - who was previously married to actress Talia Balsam - had vowed never to wed again and he poked fun at his previous reputation as a ladies' man when discussing his marriage.
He quipped: "And they said it wouldn't last. Ah, we proved them wrong!"
George also praised his "heroic" wife for her work as a human rights lawyer, pointing to her representation of a young woman, Nadia, who was sold as a slave to terrorist organisation ISIS, as an example of how she defies "risk" to represent cases she believes in.
He said: "Of course I'm proud of her. Yeah, it comes with risk.
"You spend an afternoon with that young woman [Nadia], there's no way you couldn't stand up for her. She's so brave. She's the one who's the bravest because she's in the most dangerous [situation].
"I think Amal's decision to [represent her] was, of course, heroic."
Last year, George and Amal celebrated their first anniversary with a low-key dinner at the Sunset Tower Hotel's Tower Bar in West Hollywood, and the Ocean's 11 star admitted he hadn't wanted to go all out for the occasion as he intended to make more elaborate plans as time went on.
He said at the time: "This is the paper anniversary you don't want to go too crazy on the first, you know, you've got a lot more to do."