"Wow. Everyone caved. The hackers won. An utter and complete victory for them. Wow," he wrote, then compared Hollywood to Neville Chamberlain, the British Prime Minister known for trying to appease Adolf Hitler.
"Saw @Sethrogen at JFK. Both of us have never seen or heard of anything like this. Hollywood has done Neville Chamberlain proud today," he said.
Meanwhile Apatow has been extremely vocal about the escalating events surrounding The Interview.
The writer/producer/director has known Seth Rogen and James Franco, who star in The Interview, since 1999. He was the one who discovered them, casting the pair in his TV series Freaks and Geeks.
Apatow tweeted that it was "disgraceful" that theatres pulled The Interview from screens.
"This only guarantees that this movie will be seen by more people on Earth than it would have before. Legally or illegally all will see it," he wrote.
The man behind hits such as Knocked Up and The 40-Year-Old Virgin also spoke to LA Times, saying it's "a dark future" if people suppress freedom of speech every time someone posts something online.
He says you barely see any politically minded films - which were all the rage in the 70s - anymore.
"Comedians attack power and corruption and things that feel wrong. Seth picked a very valid target to make a hilariously funny movie," he says.
"I've seen the movie. Its fantastic."
Apatow called The Interview funny and daring.
"Are we now living in a world where were not allowed to say that these are bad people? Are we not allowed to make a movie where ISIS is the bad guy now? That's been happening since Charlie Chaplin made The [Great] Dictator," he says.
"There's so much political correctness that there's almost no villains left."Intelligence officials in the US have concluded that North Korea was "centrally involved" in the hacking of Sony Pictures Entertainment in November.
The cyberattack in November resulted in a mass leak of documents including personal employee information, embarrassing emails and copies of upcoming movies.
Meanwhile, actress-turned-TV host Whoopi Goldberg says the hackers have taken their cause too far.
In a segment on her US talk show The View, she said, "For myself, I would say this to the Guardians of Peace: your name went out the window as soon as you did that, and the other thing I want to say is, I think you had Americans with you (support), until you did this ..."
However, co-host Rosie Perez disagreed with Goldberg's statement about supporting the initial leak, responding, "I wasn't with them, I didn't agree with them. I thought what they did was illegal and I thought it should have been investigated on the highest level...
"It pissed me off on a level of what we stand for in America. Seth Rogen and James Franco have a right of freedom of speech to express what they want to express through their art..."
Goldberg added: "We have the right, that's what America is, we have the right to do this..."
- AAP