Hank Azaria has been replaced in the role of Homer Simpson's African American workmate at the nuclear power plant by Alex Desert, who will voice the character for the first time in the Season 32 premiere which airs on Sunday.
A statement released by the makers of "The Simpsons" read: "We are very pleased to welcome Alex Desert, playing Carl in the Simpsons season premiere."
The move comes after the show's producers said white actors would no longer voice non-white characters.
Azaria previously stepped down from voicing Indian America Kwik-E-Mart store owner Apu Nahasapeemapetilon after "The Simpsons" was criticised for perpetuating stereotypes of Asians living in the US.
The 56-year-old comic actor explained that it "didn't feel right" continuing in the role of Apu.