In her role as neurotic chef Monica Geller in hit series Friends, Courteney Cox's character battled fertility issues with on-screen husband Chandler Bing.
But in real life, Cox would endure devastating fertility struggles too.
According to The Sun, following her marriage to David Arquette in 1999, Cox had seven miscarriages that were the result of antibodies attacking as her pregnancies tried to progress.
Cox has revealed one of the toughest things about this time in her life - at the height of Friends fame - was having to come to work each day and be funny for an audience, rather than address her heartbreak.