"What's going on, why am I losing this, why don't I have sound," an annoyed O'Donnell says.
"Who's asking for a Labour Day rundown in my ear?"
"God dammit," he says, shaking his head as his anger rises.
In the next segment, O'Donnell reads the script off a TelePrompter before saying: "There's insanity in the control room tonight."
He is visibly trying to restrain himself as the chaos continues.
"You have insanity in my earpiece," O'Donnell says before using profanity.
"F***in."
The host completely loses his composure seconds later when he blows up on his staff over noises coming from the studio.
"Stop the hammering!" O'Donnell hollers at his team.
He then gets up out of his chair and continues the tirade.
"Stop the hammering up there. Who's got a hammer? Where is it? Where's the hammer?
"Go up on the other floor. Somebody go up there and stop the hammering.
"Stop the hammering. I'll go down to the goddamned floor myself and stop it, keep the goddamned commercial break going."
He then references his boss, MSNBC President Phil Griffin.
"Call f***ing Phil Griffin, I don't care who the f*** you have to call. Stop the hammering. Empty out the goddamned control room and find out where this is going on.
"F***ing out of control s***," he says.
Warning: Explicit language