Bruce and Demi's children Rumer, 29, Scout, 26, and Tallulah, 24, were also in attendance to support their father.
During her part of the roast, Demi made a crack about their marriage, quipping: "I look at our marriage like The Sixth Sense. You were dead the whole time."
Demi also took aim at Bruce's age, bald head, music, and his Die Hard movies.
She quipped: "People wonder why our marriage came to an end, and in all honesty I think it was because some jealousy started to creep in. I think Bruce never really got over the fact that I rocked the bald look better than he did. After our divorce, he said he considered the end of our marriage his biggest failure, but Bruce, don't be so hard on yourself, you've had much bigger failures. I mean Planet Hollywood, Hudson Hawk, Striking Distance, campaigning for Michael Dukakis, turning down Clooney's role in Ocean's Eleven to focus on playing the harmonica?"
Despite cracking plenty of jokes at her ex-husband's expense, the pair were seen sharing a warm hug on stage.
In 2015, Demi discussed the affect of her divorce with Bruce on their eldest daughter Rumer, during Rumer's stint on Dancing With The Stars.
"When their father and I decided to divorce it probably had the biggest impact on her", Demi recalled.
"Media attention is tough when you are a kid, it is definitely weird to have that be such public knowledge."
Speaking about their relationship to Vanity Fair in 2005, Bruce said:
"It's hard for people to understand, but we go on holidays together.
"We still raise our kids together – we still have that bond. Demi is the mother of my children."
