Netflix initially halted filming on Dead To Me so its star could come to terms with her diagnosis and find treatment.
Applegate then committed herself to filming the third season of the show despite many challenges. She said the rest of the cast and crew were "so loving" during the experience.
"If I called them in the morning, and was like, 'Guys, I can't get down the stairs,' they were like, 'okay! We won't do today. We'll do other stuff,'" she said.
Applegate, who first shot to fame as Kelly Bundy in Married... With Children in the 1980s, is due to receive a star on the Hollywood Walk of Fame next week. She has said the ceremony will be her public debut "as a disabled person".
Applegate previously told the New York Times she can no longer walk without a cane.
She told Variety that while acting may not necessarily be in her future, she is open to other work in the industry.
"I'd like to develop stuff; I'd like to produce stuff. I've got a lot of ideas in my mind, and I just need to get them executed," she said.