The 36-year-old actor - who is best known for playing Captain America in the Marvel superhero movies - and the American comedian have quietly ended their on-again, off-again relationship.
The news has been revealed in a profile piece about Chris in the New York Times newspaper, which says that their relationship, "beloved by the internet, recently ended".
The celebrity duo - who have always kept their romance relatively low-key - initially broke up in January last year, after less than a year of dating.
But by the end of October, they were exchanging flirty messages over social media, prompting speculation that they had rekindled their relationship.