"I think companies are purposely putting out noticeably racist ads so they can get more views," he tweeted on Sunday.
"And that s**t racist/bogus so I guess I shouldn't help by posting about it. But I just gotta say tho. The 'sometimes lighter is better' Heineken commercial is terribly racist omg."
Chance told his followers that he wasn't telling them to boycott or "go off" on Heineken.
"I'm just noticing how often it happens and I think they baiting consumers and tweeters and freelancers and s**t," he wrote.
"Like I didn't wanna tweet about it so bad but its like how can u not."
Chance's original tweet about the ad received nearly 10,000 likes, although some claimed the rapper was "reaching" with his take.
"Naw, the focus is on the wine, not the people, my take on it," one user wrote.
"Just saw that joint and personally I feel your reaching here chance. It's a light beer Dawg. U know they're always saying light beer isn't as good as regular beer," another added.
But many followers thanked Chance for shining light on the ad and some claimed they would never drink the beer again.
"Wow...the beer oh so blatantly slides past the POC. Looks like I'm not drinking that trash anymore," one woman wrote.
"I can see your point Chance. It's the subtle and subliminal messages that do the most harm," another added. "This may be intentional, then again maybe not. Only the marketing team knows the true intent."
"What in the hell? You're absolutely right. That was terrible," one fan wrote. "Watching the bottle pass all the black folks, into the arms of a white girl was painful."
It appears the ad has since been removed from HeinekenUSA's YouTube page.
Bjorn Trowery, a spokesman for the company, told DailyMail.com that Heineken "missed the mark" with the commercial.
"For decades, Heineken has developed diverse marketing that shows there's more that unites us than divides us," Trowery said.
"While we feel the ad is referencing our Heineken Light beer - we missed the mark, are taking the feedback to heart and will use this to influence future campaigns."