The Grammy-winning singer's confirmation about the residency comes after much online speculation, including some of her own Vegas-themed tweets.
She said in an interview on GMA that the show will feature her greatest hits as well as new material.
"I'm definitely ready," she said in a taped interview, adding that she's training five hours each day.
Spears' helicopter hovered in the desert above her fans, who were holding giant cards that formed a 10-story-tall picture of her. The singer stepped off the aircraft and said she was feeling sick.
After a second - and live - interview with GMA, she headed back to the helicopter, barely smiling and offering little more than a wave.
A tweet about the experience later showed up on her Twitter profile.
"Y'all that will be the last time u EVER see me in a helicopter. Love u @GMA & that was INCREDIBLE but helicopters are not for this girl :(," it read.
Tickets for Britney: Piece of Me go on sale September 20. Prices range from $59 to $179.
She'll be the city's first pop music resident artist, according to Kurt Melien of Planet Hollywood parent company Caesars Entertainment, and her show "will revolutionise the entertainment landscape in Las Vegas".
The show will take place in an "intimately-sized" theater with nightclub touches, including table and bottle service.
Spears, who debuted on the music scene in 1999, has released seven platinum-plus albums. She has more than a dozen Top 10 hits, including Toxic, Gimme More and Oops!... I Did It Again.
She released a new song, Work B****, this week. It's from her untitled eighth album, due out December 3, which will include songs about her ex-fiance Jason Trawick.
- AP
