In the clip, the famously modest star appears close to tears as he accepts the praise, kicking out his leg in a mock "shucks" and nodding in thanks.
Aronofsky's film is adapted from a play by Samuel D. Hunter that focuses on the life of a man living with obesity named Charlie, who is seeking to reunite with his estranged teenage daughter, played by Stranger Things star Sadie Sink, after abandoning his wife and child for a gay lover. Charlie became morbidly obese after developing a compulsive eating disorder to deal with his lover's death.
It marks Brendan's first lead role in a movie since straight-to-DVD thriller Breakout in 2013, with fans primed for his major Hollywood comeback for many months, since he went viral in a rare interview on TikTok last year.
Fraser told Variety in a piece published last week that he took on this role of Charlie in The Whale to push himself.
"I wanted to know what I was capable of," he said.
Fraser, who has not had any major roles in more than a decade, said he wanted to fully immerse himself in Charlie's character and become "unrecognisable".
"If there's no risk, then why bother?" Fraser said. "I want to learn from the people I'm working with at this point in my career.
"I've had such variety, a lot of high highs and low lows, so what I'm keen for, in the second half of my time doing this, is to feel like I'm contributing to the craft and I'm learning from it.
"This is a prime opportunity. I wanted to disappear into it. My hope was that I would become unrecognisable."
The actor also has had roles this year in Martin Scorsese's latest western film Killers Of The Flower Moon and played the leading antagonist in HBO's now-cancelled Batgirl movie as Garfield Lynns – the villain known as Firefly.