The Big Bang Theory, one of the most-watched shows in the U.S., will wrap up next year after its 12th season, bringing an end to television's longest-running multi-camera comedy.
The sitcom, created by producers Chuck Lorre and Bill Prady, blossomed from a minor hit when it debuted in 2007 to the most-watched comedy on TV in certain years.
It was the second-most-watched comedy this past season, trailing only the "Roseanne" reboot.
The show has also been well-received by the industry, earning 52 Emmy nominations and 10 wins.
"The Big Bang Theory" has been an anchor for CBS, the most-watched U.S. TV network, and its absence will force the network to look for a new hit. CBS and Warner Bros., the studio that produces the sitcom, have already created a spinoff, "Young Sheldon," about one of the main characters as a child.