The Big Bang Theory actor and the art director tied the knot during an intimate ceremony at the Rainbow Room in New York on Saturday, a representative for the star confirmed to the New York Post newspaper's Page Six column.
The couple first sparked engagement rumours in 2014, and last year Jim, 44, took to Instagram to gush over his partner as they celebrated their 14-year anniversary.
He wrote at the time: "I met this guy (the one with the mic) 14 years ago today and it was the best thing that ever happened to me, no contest. One of his greatest gifts to me is that he no longer takes me to sing karaoke. Also, I believe this was a selfie with an actual camera, as our phones couldn't do that back then hahaha! (sic)"
Jim came out as gay in 2012 after he said in an interview with the New York Times that he had been in a relationship with Todd for 10 years.