Angelina's son Maddox, 13, was born in Cambodia and he is believed to be involved in the movie's production.
Her directorial debut, In the Land of Blood and Honey, was released in two languages and the new project will be shot in both Khmer and English.
Just last month Angelina's husband Brad Pitt signed a deal with Netflix to produce and star in online comedy 'War Machine'.
The deal means Netflix has agreed to fund and distribute the film and is the combined efforts of his Plan B production house and the service.
The movie is set to start shooting in August, and Animal Kingdom helmer David Michôd will take on directing duties.
Netflix have confirmed War Machine will be eligible for Oscar and Emmy nominations, despite not having a conventional release.
- Bang! Showbiz