The 37-year-old comic realised not long after she started dating Chris Fischer - who she married in February 2018 following a whirlwind three-month romance - that his "brain was a little different" and explained it's because he has the condition, which is a form of developmental disorder autism and can cause difficulties with communication and social interaction.
In her upcoming Netflix special 'Amy Schumer: Growing' she told a crowd in Chicago: "I knew from the beginning that my husband's brain was a little different than mine. I have to start this over because I really want to get this right because I love him very much.
"My husband was diagnosed with what used to be called Asperger's. He has autism spectrum disorder. He's on the spectrum. And there were some signs early on."
The 'I Feel Pretty' star - who is expecting her first child with the chef - went on to admit she has shared a lot of "'Huh' moments" with her husband, starting from when she fell over on one of their first dates.