Depp, an accomplished guitar player, has recorded with the likes of Oasis and Marilyn Manson in the past and he performed on stage with the latter at the Hollywood's Roxy Theatre in November.
Scarlett Johansson, Russell Crowe, Robert Downey Jr and Depp's Mortdecai co-star Gwyneth Paltrow are among those whose musical endeavours have gained notoriety through their acting fame.
Depp, though, is content in being a low-key musician.
"The kind of luxury now is, anybody with a certain amount of of success, if you have a kind of musical being, you can go out and start a band and capitalise on your work in other areas," the Pirates of the Caribbean star said.
"But I hate the idea, 'come see me play the guitar because you've seen me in 12 movies'.
"It shouldn't be (that way). You want the people who are listening to the music to only be interested in the music."
Depp has spent the past fews days in the German capital promoting Mortdecai, a David Koepp-directed action comedy based on the Kyril Bonfiglioli's trilogy of novels first published in the 1970s.
Also starring Paul Bettany, Jeff Goldblum and Olivia Munn, the film sees Depp assume the role of charismatic anti-hero Charlie Mortdecai, an opportunistic art dealer caught up in a race to recover a stolen painting.
It's yet another eccentric, larger-than-life role for Depp and one he described as "way too much fun".
"We'd get the giggles (on set) and it'd last forever," Depp said.
Mortdecai opens in New Zealand on January 29.
- AAP