A committee aide said Banking Chairman Tim Johnson plans a vote as soon as possible, potentially next week. Yellen probably will win support from most Democrats and a handful of Republicans.
Her testimony represented a strong defense of the Fed's policies pursued under Chairman Ben Bernanke, which were launched to combat the Great Recession and the financial crisis.
The latest efforts include spending $85 billion a month on bond purchases, which are intended to lower long-term interest rates and promote faster economic growth.
The Fed has said it plans to keep its key short-term rate near zero at least until unemployment falls to 6.5 percent. The rate is now 7.3 percent.
Some Republicans expressed concerns at the hearing about the bond purchases, which have swelled the Fed's balance sheet to $3.8 trillion. They are worried that the money flooding into the financial system is inflating stock and real estate prices. And that could be creating asset bubbles, which would have a disastrous impact on the economy if they burst.
Yellen repeatedly assured senators that the Fed is mindful of those risks. But she cautioned that there were other dangers if the Fed pulled back prematurely. The economy could weaken further and unemployment could rise.
Pressed by Republicans to specify when the central bank might begin scaling back the bond purchases, Yellen said Fed policymakers assess the risks and benefits of the bond purchase program each time they meet.
"The committee is looking for ... signs of growth that are strong enough to promote continued progress" in the labor market. She said "there is no set time that we will decide to reduce the pace of our purchases."
The Fed has said that it wants to see stronger data before it reduces the stimulus.
Recent reports have been encouraging. The government said last week that the economy added 204,000 jobs in October, and many more in the previous two months than initially reported. And the economy grew at a 2.8 percent annual rate from July through September, the fastest pace in a year.
Private economists viewed Yellen's comments as a strong signal that Bernanke's policies will continue at the Fed.
The central bank's last meeting of the year is Dec. 17-18, and it will meet again in January, which will be Bernanke's last meeting as chairman. He steps down Jan. 31 after eight years at the helm.
Many economists believe that the earliest the Fed would begin reducing the bond purchases is at the March meeting. That would be Yellen's first as chairman, presuming she is confirmed by then